45 research outputs found
A semantic foundation for hidden state
We present the first complete soundness proof of the antiframe
rule, a recently proposed proof rule for capturing information hiding
in the presence of higher-order store. Our proof involves solving a
non-trivial recursive domain equation, and it helps identify some of the
key ingredients for soundness
An Implementation of Caml-Light with existential types
Résumé disponible dans le fichier PD
Uniqueness Typing for Resource Management in Message-Passing Concurrency
We view channels as the main form of resources in a message-passing
programming paradigm. These channels need to be carefully managed in settings
where resources are scarce. To study this problem, we extend the pi-calculus
with primitives for channel allocation and deallocation and allow channels to
be reused to communicate values of different types. Inevitably, the added
expressiveness increases the possibilities for runtime errors. We define a
substructural type system which combines uniqueness typing and affine typing to
reject these ill-behaved programs
Increased insolation threshold for runaway greenhouse processes on Earth like planets
Because the solar luminosity increases over geological timescales, Earth
climate is expected to warm, increasing water evaporation which, in turn,
enhances the atmospheric greenhouse effect. Above a certain critical
insolation, this destabilizing greenhouse feedback can "runaway" until all the
oceans are evaporated. Through increases in stratospheric humidity, warming may
also cause oceans to escape to space before the runaway greenhouse occurs. The
critical insolation thresholds for these processes, however, remain uncertain
because they have so far been evaluated with unidimensional models that cannot
account for the dynamical and cloud feedback effects that are key stabilizing
features of Earth's climate. Here we use a 3D global climate model to show that
the threshold for the runaway greenhouse is about 375 W/m, significantly
higher than previously thought. Our model is specifically developed to quantify
the climate response of Earth-like planets to increased insolation in hot and
extremely moist atmospheres. In contrast with previous studies, we find that
clouds have a destabilizing feedback on the long term warming. However,
subsident, unsaturated regions created by the Hadley circulation have a
stabilizing effect that is strong enough to defer the runaway greenhouse limit
to higher insolation than inferred from 1D models. Furthermore, because of
wavelength-dependent radiative effects, the stratosphere remains cold and dry
enough to hamper atmospheric water escape, even at large fluxes. This has
strong implications for Venus early water history and extends the size of the
habitable zone around other stars.Comment: Published in Nature. Online publication date: December 12, 2013.
Accepted version before journal editing and with Supplementary Informatio
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The Latest Mars Climate Database (MCD v5.1)
For many years, several teams around the world have developed GCMs (General Circulation Model or Global Climate Model) to simulate the environment on Mars. The GCM developed at the Laboratoire de Météorologie Dynamique in collaboration with several teams in Europe (LATMOS, France, University of Oxford, The Open University, the Instituto de Astrofisica de Andalucia), and with the support of ESA and CNES is currently used for many applications. Its outputs have also regularly been compiled to build a Mars Climate Database, a freely available tool useful for the scientific and engineering communities. The Mars Climate Database (MCD) has over the years been distributed to more than 150 teams around the world. Following the recent improvements in the GCM, a new series of reference simulations have been run and compiled into a new version (version5.1) of the Mars Climate Database, released in the first half of 2014.
To summarize, MCD v5.1 provides:
- Climatologies over a series of dust scenarios: standard year, cold (ie: low dust), warm (ie: dusty atmosphere) and dust storm, all topped by various cases of Extreme UV solar inputs (low, mean or maximum). These scenarios differ from those of previous versions of the MCD (version 4.x) as they have been derived from home-made, instrument-derived (TES, THEMIS, MCS, MERs), dust climatology of the last 8 Martian years.
- Mean values and statistics of main meteorological variables (atmospheric temperature, density, pressure and winds), as well as surface pressure and temperature, CO2 ice cover, thermal and solar radiative fluxes, dust column opacity and mixing ratio, [H20] vapor and ice columns, concentrations of many species: [CO], [O2], [O], [N2], [H2], [O3], ...
- A high resolution mode which combines high resolution (32 pixel/degree) MOLA topography records and Viking Lander 1 pressure records with raw lower resolution GCM results to yield, within the restriction of the procedure, high resolution values of atmospheric variables.
- The possibility to reconstruct realistic conditions by combining the provided climatology with additional large scale and small scale perturbations schemes.
At EGU, we will report on the latest improvements in the Mars Climate Database, with comparisons with available measurements from orbit (e.g.: TES, MCS) or landers (Viking, Phoenix, MSL)
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Modeling the martian atmosphere with the LMD global climate model
Our Global Climate Model (GCM) of the Martian atmosphere is the result of twenty years of ongoing collaboration between our teams and has matured to the point of enabling to study the main cycles (dust, CO2, water) of present-day and past Martian climates.
At the 2014 scientific assembly, we will report on the latest developments and improvements of our GCM, and also present the latest version of the Mars Climate Database (version 5.1) that is derived from GCM outputs, along with comparisons with available measurements (from TES, MCS, Viking, Phoenix, Curiosity, etc.)
Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin antitumor effects
Cisplatin is a potent chemotherapeutic drug that is widely used in the treatment of various solid cancers. However, its clinical effectiveness is strongly limited by frequent severe adverse effects, in particular nephrotoxicity and chemotherapy-induced peripheral neuropathy. Thus, there is an urgent medical need to identify novel strategies that limit cisplatin-induced toxicity. In the present study, we show that the FDA-approved adenosine A2A receptor antagonist istradefylline (KW6002) protected from cisplatin-induced nephrotoxicity and neuropathic pain in mice with or without tumors. Moreover, we also demonstrate that the antitumoral properties of cisplatin were not altered by istradefylline in tumor-bearing mice and could even be potentiated. Altogether, our results support the use of istradefylline as a valuable preventive approach for the clinical management of patients undergoing cisplatin treatment